Premixed insulin AnAlogues in diAbetes And gestAtionAl diAbetes mellitus

The most spectacular discovery of this century in the therapy of diabetes is insulin. The source of insulin in the past was from animal pancreas which had amino acid sequence different from that of human insulin. This resulted in immunological reactions and inadequate control of plasma glucose due to its pharmacokinetic actions. To overcome the dependence of animal source for the extraction of insulin, DNA recombinant technology was developed to produce insulin. This insulin preparation had amino acid sequence identical to the insulin produced by human pancreas.